Methylenetetrahydrofolate reductase gene (C677T and A1298C) polymorphisms and hyperhomocysteinemia as risk factors for Myocardial Infarction

Eissa, Adil A ; Rasool, Chiman Saleem ; Mustafa, Majeed Hussein

Abstract

Conflicting data concerning the association between methylenetetrahydrofolate reductase gene MTHFR (C677T and A1298C) polymorphisms with or without hyperhomocysteinemia and myocardial infarction exists and data from developing countries is limited thus, a current study initiated to study whether any association exist between the above polymorphisms and myocardial infarction among Kurdish patients from Duhok province/Iraq.

A case-control study was performed in Azadi teaching hospital/Duhok/Iraq and included 75 patients with acute myocardial infarction and 75 age and sex-matched normal controls. All the patients and controls had their methylenetetrahydrofolate reductase gene analyzed for C677T and A1298C polymorphism using polymerase chain reaction/restriction fragment length polymorphism technique as well as their homocysteine level.


Keyword(s)

Hyperhomocysteinemia; Kurds; Methylenetetrahydrofolate reductase; Myocardial infarction

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