Protective role of nanoemulsion containing roman chamomile oil against mitomycin C-induced toxicity in Ehrlich ascites carcinoma bearing mice

Al-Otaibi, Waad A ; Alkhatib, Mayson H ; Wali, Abdulwahab Noor

Abstract

Mitomycin-C (MC), an anticancer agent, induces oxidative stress in normal tissues causing severe toxicity. The present study aimed to evaluate whether the side effects of MC may be diminished by the incorporation of MC into nanoemulsion containing Roman chamomile oil (RCM-NE). Fifty mice were equally divided into five groups. The first and second groups were the control and the untreated Ehrlich ascites carcinoma bearing mice (EAC), respectively, while the other three groups were EAC-bearing mice treated once intraperitoneally with a dose of 200 µL of RCM-NE, 1 mg/kg−1 MC/200 µL normal saline, and 1 mg/kg−1 MC/200 µL RCM-NE. The protective effect of the RCM-NE was examined by measuring the alterations in complete blood count, organs weight indices, and levels of serum biochemical parameters. The oxidative stress was assessed by measuring lipid peroxidation and enzyme activities of catalase, superoxide dismutase, glutathione reductase, and thioredoxin reductase-1. MC-RCM-NE has significantly reduced the toxicity of MC on the white blood cells and platelets. It improved the renal and cardiac biomarker levels and the antioxidants of the kidney, heart, and thymus. The protective effect of the RCM-NE on the blood and organs against MC toxicity was associated with the decreasing of oxidative stress and maintaining the activity of the antioxidants.

Keyword(s)

Cardiotoxicity; Nephrotoxicity; Oxidative stress; Thymic atrophy

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