A 3D Co(II) compound: Crystal structure and protective activity on chronic nephritis

Shi, Xiu-Zhen ; Guo, Ai-Li ; Fu, Kai ; He, Yan ; Li, Qin ; Luo, Qiong

Abstract

In the current study, via applying a mixed-ligand strategy, a Co(II) coordination polymer that is, {[Co4(3-dpyb)2 (odpa)2(H2O)3]·4H2O}n (1) [where 3-dpyb is N,N′-bis(3-pyridinecarboxamide)-1,4-butane, and H4odpa represents 4,4′-oxydiphthalic acid] is produced through reaction between two organic ligands and Co(NO3)2·6H2O in the water and DMF mixed solvents. For the treatment of chronic nephritis, real time RT-PCR is employed for measuring the AMPK signaling pathway activation, and ELISA detection kit is applied to evaluate inflammatory cytokines content released into plasma. Computer simulation has revealed that the activity of the proposed candidate is only from the carboxyl function groups, however, nitrogen atoms from both amide and pyridine groups only showed limited activity to the protein.


Keyword(s)

Coordination polymer, Chronic nephritis, Computer simulation

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