Free-radical scavenging and α-glucosidase inhibitory activities of pyrazoline and pyrazole heterocyclic compounds

Abstract

A total of fifty pyrazolines 3a-y and pyrazoles 4a-y have been evaluated for their free-radical scavenging and α-glucosidase inhibitory activities. The pyrazolines 3e, 3h, 3p, 3s and pyrazole 4e have been identified as potent ABTS.⁺ free-radical scavengers. The thiophene substituted pyrazoline 3s has shown potent ABTS.⁺ free radical scavenging activity compared to thiophene substituted pyrazole 4s. Furanyl (4r), pyrazolyl (4t), 2-chloropyridinyl (4u-w), 2-chloroquinolinyl (4x) and 4-chlorocoumarin (4y) pyrazoles have displayed moderate ABTS.⁺ free-radical scavenging activity. Pyrazoline 3i and pyrazole 4b have shown moderate DPPH free-radical scavenging activity.