Docking, synthesis and evaluation of N-(2-(4-methoxy-2-oxo-1-phenyl/methyl-1,2-dihydroquinolin-3-yl)-2-oxoethyl)-N-substitutedphenylbenzenesulfonamide derivatives as hypoglycemic agents

Abstract

The current research work involves in silico docking studies, synthesis, characterisation and study on hypoglycemicactivity of a series of N-(2-(4-methoxy-1-methyl/phenyl-2-oxo-1,2-dihydroquinolin-3-yl)-2-oxoethyl)-N-substitutedprimaryamino) -benzenesulfononamides [IVa/b (1-6)]. Compounds exhibit prominent anti-diabetic activity by glucose oxidase peroxidase (GOD-POD) method which involves measurement of average serum glucose levels in mg/dl as well as conserved hydrogen bonds with one or more amino acid residues in the active pocket of murine 11β-hydroxysteroid dehydrogenase domain. Among all the synthesized compounds, compound IVb2 shows prominent anti-diabetic activity and higher Moldock score as compared to standard drug Glibenclamide. Structural analysis of the synthesized compounds has been done by standard spectroscopic techniques.