Micellar parameters and thermodynamics of interaction of fluoroquinolone drugs with cetyldimethylethylammonium bromide

Hoque, Md. Anamul; Ahsan, Sk. Md. Ali; Khan, Mohammed Abdullah; Hossain, Mohammed Delwar

Abstract

Interaction of fluoroquinolone antibiotic drugs, viz., ciprofloxacin hydrochloride, levofloxacin hemihydrate and lomefloxacin hydrochloride, with the cationic surfactant cetyldimethylethylammonium bromide (CDMEAB) has been studied by conductance measurements in water and in the presence of salts such as NaCl, Na2SO4 and Na3PO4·12H2O over the temperature range of 298.15–318.15 K. Two critical micelle concentrations (c*) are obtained for drug-CDMEAB systems in all the cases. The change of c* values of CDMEAB due to the addition of the drugs is indicative of the interaction between drugs and CDMEAB. Favourable micellization of drug-CDMEAB systems is observed in the presence of salts. The ∆G0m values were negative in all the cases. The values of ∆H0m and ∆S0m reveal that the binding interactions between drug and CDMEAB in water are both electrostatic and hydrophobic in nature. The existence of linear correlation between ∆H0m and ∆S0m values is observed in all cases.


Keyword(s)

Solution chemistry, Surfactants, Micellization, Drug-surfactant interactions, Surfactant-drug interactions, Hydrophobic interactions, Thermodynamic parameters, Cetyldimethylethylammonium bromide, Fluoroquinolones

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