Polylactic acid coated SBA-15 functionalized with 3-aminopropyl triethoxysilane

Ananthi, Nallamuthu ; Varghese, Jose ; Sakthipriya, Pachiannan ; Rachel, Gunalan

Abstract

In the present study, a pH responsive polylactic acid coated SBA-15 functionalized with 3-aminopropyl triethoxysilane is reported. PLA has been coated on the functionalized SBA-15 by formation of amide linkage between amine functionalized SBA-15 and PLA. The amide linkage is confirmed by FTIR spectroscopic data. The materials are well characterized by FTIR, SEM, EDAX and XRD data. Using the PLA coated functionalized SBA-15 the controlled release of the drug ibuprofen has been studied. The successful delivery of ibuprofen has been achieved on the basis of its pH response.


Keyword(s)

Mesoporous materials, Mesoporous silica, Silica, SBA-15, Functionalized SBA-15, Drug delivery

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