Study of Kirkwood-Buff integrals of selected polar and nonpolar amino acids in aqueous-streptomycin sulphate solutions at 298.15 K


NAIN, ANIL KUMAR; Bisht, Yogita

Abstract

The Kirkwood-Buff (K-B) integrals can play pivotal role in understanding the physiochemical action of drugs on proteins. The Kirkwood-Buff theory can be used to characterize the intermolecular interactions of amino acids with drug by directly calculating G11, G22 and G12 parameters which represents solute-solute, solvent-solvent and solute-solvent interaction respectively. The K-B integrals of nonpolar amino acids glycine, l-alanine, l-valine, l-isoleucine and polar amino acids l-histidine and l-arginine in aqueous-streptomycin sulphate solutions (1% and 2% streptomycin sulphate in water, w/w) have been calculated from experimental data of ultrasonic speed and density at 298.15 K. All the results obtained by theoretical calculations are in good agreement with that of experimental results.

Keyword(s)

Kirkwood-Buff integrals, Amino acids, Streptomycin sulphate, Apparent molar volume, Density, Ultrasonic speed

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