MICROWAVE ASSISTED TEMPLATE SYNTHESIS OF METAL BASED EGFR, TRK INHIBITORS, MOLECULAR DOCKING AND IN VITRO BIOLOGICAL STUDIES

Jain, Preeti ; Singh, Vandna ; Tripathi, Vishwas

Abstract

ABSTRACT: Metal based biologically active compounds were synthesized by microwave assisted template condensation method and characterized by spectro-analytical techniques like molar conductance, UV-Vis, FTIR, Mass spectroscopy and TGA. The metal was arranged in octahedral geometry surrounded by tetradentate ligand framework. The binding affinity of all the metal complexes was evaluated theoretically by molecular docking studies against epidermal growth factor receptor (EGFR) and tyrosine kinase (TRK) receptor molecules which were further verified by in vitro anticancer activity. Complex [Cr(C16H11N4O2)(NO3)2]NO3 showed potent in vitro cytotoxicity (IC50 value 39.5μM) against SCC4 cancer cell line. Antioxidant study was also performed by DPPH assay and significant results were found. [Fe(C16H11N4O2)(OAc)2]OAc and [Cr(C16H11N4O2) (OAc)2]OAc are most effective antioxidants with 78.7% and 76.8% free radical scavenging activity respectively.

Keyword(s)

Antioxidant , EGFR, microwave method , Molecular docking, Template synthesis

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