Synthesis, spectral studies and antibacterial activity of iron(III) complexes with  hydrazone functionalized ligands: X-Ray structure determination of a novel  five coordinate complex containing labile ligands

Reddy, katreddi hussain

Abstract

Iron(III)  complexes having general formula FeLCl2 [where, L = 2-acetylpyridine acetoylhydrazone(APAH),       2-acetylpyridine benzoylhydrazone(APBH),   2-acetylthiophene acetoylhydrazone(ATAH), and 2-acetythiophene benzoylhydrazone(ATBH) ] have been synthesized characterized based on molar conductivity, electronic and IR spectroscopy. The structure of iron(III) complex  with APBH ligand  is  determined using single crystal X-Ray crystallography .  The complex crystallizes in monoclinic space group P21/n with  a = 7.8490(6) Å, b = 15.1018(11) Å, c = 13.2263(10) Å,    α = 90°, β=100.183(3)°, γ = 90°,   V = 1543.1(2) Å3 and  Z = 4 with central Fe(III)  ion coordinated one tridentate APBH ligand. The iron is              5- coordinate binding with one organic (hydrazone)   unit and two labile chloride ligands. The hydrazone acts as NNO –tridentate donor system.  Iron is coordinated by pyridine ring nitrogen, azomethine nitrogen and benzoyl oxygen atoms and the two chloride ligands bind with metal completing distorted square pyramidal structure.   The iron complexes are screened for their anti-bacterial activities against Pseudomonas aureoginos and Bacillus cereus Acetoyl hydrazones show more antibacterial activity than  the corresponding benzoyl hydrazones.  Functional groups of azomethine carbon are varied. The hydrazones having a methyl/ and pyridine groups show more anti bacterial activity.  The complexes show more activity than the ligands.

 


Keyword(s)

Key Words : Iron(III) complexes, Trifunctional donor ligands, Crystal structure, Antibacterial  activity

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