Benzimidazolium picrate single crystal: Synthesis, growth, characterization and their biological activity

Vadivelan, Ganesan ; Gohulavani, Grahandurai ; Saravanabhavan, Munusamy ; Murugesan, Venkatesan ; Sekar, Marimuthu

Abstract

Knowledge on charge-transfer complexes of drugs is important to understand the drug-receptor binding mechanism. Here, we have been synthesized the organic charge transfer complex of Benzimidazolium picrate (BP) and confirmed its molecular structure and carbon skeleton by 1H and 13C NMR spectral analysis. Asymmetric unit of BP consists of one benzimidazolium cation and a monovalent anion of picric acid. Decomposition pattern and thermal stability BP have been investigated using TG/DTA analysis. The interaction of the compound with calf thymus DNA is investigated by electronic absorption spectroscopy which indicates that the compound could interact with DNA through intercalation. The CT complex demonstrated significant free radical scavenging with 2,2-diphenyl-2-picryl-hydrazyl. The BP complex has been also screened for its antimicrobial activity.


Keyword(s)

Benzimidazolium picrate; Charge-transfer complex; 2,2-Diphenyl-2-picryl-hydrazyl

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