Fe(III), Co(II) & Cu(II) Complexes of N,N’-Bis[2-salicylideneamino]ethane-1,2-diamine: Preparation, characterisation and in vitro antibacterial activity

Joshi, Shital ; Sharma, Komal ; Jadham, Jaishri ; Sharma, Dr. (Mrs.) Uma


Salicylaldehyde derived hexadentate Schiff base N,N’-Bis[2-salicylideneamino]ethane-1,2-diamine (TTS) and its complexes with Fe(III), Co(II) and Cu(II) metal ions have been prepared and characterised by elemental analysis, UV-visible, IR, 1H NMR, EPR spectral analysis, mass spectrometry and XRD method. In vitro antibacterial activity of the Schiff base and its metal complexes against Gram positive bacterial strains Staphylococus aureus, Bacillus subtilis and Gram negative bacterial strains Enterobacter, Escherichia coli has revealed that the metal complexes are more active to the bacterial strains as compared to that of the Schiff base. The Co-TTS has the highest antibacterial activity against Escherichia coli, while the Fe-TTS complex is highly active against Enterobacter, Staphylococcus aureus and Bacillus subtilis.


Hexadentate Schiff base; Fe(III), Co(II), Cu(II) metal complexes; Biological activity

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