DOI:

Mixed ligand complex of monovalent Copper with benzimidazole derivatives and alanine: synthesis, characterization and antimicrobial studies


Mixed ligand complexes of transition metal ions exhibit broad range of biological activities. Schiff bases containing azomethine (C=N) group and amino acids are versatile compounds for design of ternary complexes. An attempt has been made to synthesize novel copper(I) complex by the reaction of two ligands, 2-N-(4-methyl phenyl ethanimine) benzimidazole [MPEIBI] as L1 and an amino acid Alanine as L2, and freshly prepared Cuprous Chloride solution in 1:1:1 molar ratio through conventional reflux method. The synthesized ligand and Copper(I) complex are characterized by elemental analysis, molecular weight determination, magnetic moment measurement, spectroscopic techniques. These synthesized compounds were evaluated for antimicrobial studies against bacterial strains, B. subtilis, E. coli and fungal pathogens,hy T. ressei, C. albicans. The Cu(I) complex has shown remarkable antibacterial and antifungal activity.

RANKA, MAMTA ; YADAV, POONAM ; SHARMA, SHOBHANA ; KUMARI, SUMAN ; -, SEEMA

Abstract

Mixed ligand complexes of transition metal ions exhibit broad range of biological activities. Schiff bases containing azomethine (C=N) group and amino acids are versatile compounds for design of ternary complexes. An attempt has been made to synthesize novel copper(I) complex by the reaction of two ligands, 2-N-(4-methyl phenyl ethanimine) benzimidazole [MPEIBI] as L1 and an amino acid Alanine as L2, and freshly prepared Cuprous Chloride solution in 1:1:1 molar ratio through conventional reflux method. The synthesized ligand and Copper(I) complex are characterized by elemental analysis, molecular weight determination, magnetic moment measurement, spectroscopic techniques. These synthesized compounds were evaluated for antimicrobial studies against bacterial strains, B. subtilis, E. coli and fungal pathogens,hy T. ressei, C. albicans. The Cu(I) complex has shown remarkable antibacterial and antifungal activity.

Keyword(s)

Mixed ligand complex; Azomethine; Benzimidazole; Alanine; Antibacterial; Antifungal.

Full Text: PDF (downloaded 298 times)

Refbacks

  • There are currently no refbacks.
This abstract viewed 380 times