Synthesis of cage heterocycles containing tetrahydrofuran and pyran ring systemvia Grignard addition and ring-closing metathesis

Kotha, Sambasivarao ; Cheekatla, Subba Rao

Abstract

Several cage compounds containing tetrahydrofuran and pyran rings have been reported by using the Grignard additionand ring-closing metathesis as key steps. Cage hemiketal derivatives have been generated due to the proximity of twocarbonyl groups in cage dione. These cage heterocycles have been derived from readily available starting materials such as1,4-hydroquinone and dicyclopentadiene.


Keyword(s)

Cage heterocycles, tetrahydrofuran ring system, Grignard addition, ring-closing metathesis (RCM),cage hydroxyethers, transannular cyclization

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