Condensation of nicotinaldehydes with phenylethanones: A convenient synthesis and biological activities of chalcones

Bhimapaka, China Raju ; Somanaboina, Ramya ; Kolla, Sai Teja ; Kurma, Siva Hariprasad ; Ali, Zehra ; Ganji, Praveena ; Tiwari, Ashok Kumar ; Reddy Shetty, Prakasham

Abstract

Claisen-Schmidt condensation of nicotinaldehydes 1a-e with various phenylethanones 2a-d in the presence of base at room temperature have provided chalcones 3a-t. All the synthesized compounds have been evaluated for their anti-microbial, free-radical scavenging and α-glucosidase inhibitory activities. Compounds 3d and 3h have been identified as potent anti-fungal and moderate anti-bacterial agents. Compounds 3c, 3h, 3k-m and 3q have shown α-glucosidase inhibitory activity.

Keyword(s)

Nicotinaldehydes, chalcones, anti-microbial activity, α-glucosidase inhibitory activity

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