Synthesis and antimicrobial activity of some hybrid 2-aryl-4-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepine derivatives
Some new hybrid 2-aryl-4-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepines have beensynthesised which possessed the pyrazole and benzodiazepine heterocycles 2a-t. Antimicrobial evaluation of the synthesizedcompounds have been carried out against different strains of bacteria like E. coli, P. aeruginosa, S. aureus and S. pyogenesand fungal strains like C. albicans, A. niger and A. clavatus using serial dilution method. The newly synthesized compounds2i, 2j, 2k, 2l, 2m, 2q and 2t have shown significant activity against the above mentioned strains. The reported compounds inthe present paper are supported by IR, 1H and 13C NMR, and LC-MS spectral analysis.
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