Synthesis and anti-inflammatory and analgesic activity of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones

Rajanarendar, E ; Sanjeev, Rella ; Thirupathaiah, Kammari

Abstract

A new series of 5-(1H-benzo[d] imidazol-2-yl) methyl)-3-(3,5-dimethyl-4-isoxazolyl)-2-aryl-thiazolidin-4-ones 4 have been accomplished by a simple synthetic protocol. The reaction of 4-benzalamino-3,5-dimethylisoxazoles 3 with mercapto succinic acid furnishes 2-(3-(3,5-dimethyl-4-isoxazolyl)-4-oxo-2-aryl thiazolidin-5-yl) acetic acids 3, which are then cyclized to the title compounds viz., isoxazolyl thiazolyl benzimidazoles 4 on treatment with 1,2-phenylene diamines. The title compounds 4 have been screened for their anti-inflammatory and analgesic activity.

Keyword(s)

Isoxazolyl thiazolyl benzimidazoles, cyclocondensation, anti-inflammatory activity, analgesic activity

 


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