Potassium alum as a naturally mineral and economical catalyst for the one-pot, multi-component and clean synthesis of 2-oxo(thio)-1,2,3,4-tetrahydropyrimidines and N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates

Mohamadpour, Farzaneh

Abstract

An environmental friendly synthetic route for potassium alum catalyzed one-pot multi-component synthesis of biologically active 2-oxo(thio)-1,2,3,4-tetrahydropyrimidines and N--aryl-3-aminodihydropyrrol-2-one-4-carboxylates has developed. The present synthetic route has the notable advantages of natural, mineral, inexpensive and non-toxic catalyst, mild reaction conditions, eco-friendly, one-pot and good to high yield of biological active products. This method is simple for work up and the compound formed filtered and purified just by simple crystallization.


Keyword(s)

Potassium alum, 2-Oxo(thio)-1,2,3,4-tetrahydropyrimidines, N-aryl-3-aminodihydropyrrol-2-one-4-carboxylate, Naturally mineral catalyst, Multi-component synthesis.


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