Stereoselective synthesis towards (+)-trans-kumausyne employing vinylogous Mukaiyama type reaction on an α-chloro sulfide
A stereoselective synthesis towards (+)-trans-kumausyne is disclosed. The key steps of the synthesis include stereoselective C-C formation employing vinylogous Mukaiyama type reaction of an α-chloro sulfide with 2-trimethylsiloxy furan and base-catalyzed isomerization followed by intramolecular oxa-Michael reaction.
α-Chloro sulfide, Mukaiyama type reaction, oxa-Michael addition, (+)-trans-Kumausyne, 2-trimethylsiloxy furan.
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