Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido- [4,5-d]pyrimidine derivatives as potent antimicrobial agents


Prasoona, G ; Kishore,, B ; Brahmeshwari, G


Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d] pyrimidines 5/6 has been achieved by reaction of 2-amino-4-aryl-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles 4 with formaldehyde/urea. The key intermediate 4, is obtained by reaction of 2-aminobenzaldehyde 1 with aromatic aldehyde and malononitrile by a three-component one-pot process. The newly synthesized title compounds 5/6 have been evaluated for their in vitro antimicrobial activity. Compounds 5 and 6 exhibit potent antimicrobial activity compared to that of standard drugs.


Keywords: Multi-component reaction, benzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles, cyclization, benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidines, antimicrobial activity


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