P2O5-mediated Friedel-Crafts acylation of activated arenes with carboxylic
acid as acylating agent

 

Kalshetti, Rupali G; Mandle, Ram D; Kamble, Sanjay P; Sudalai, Arumugam

Abstract

P2O5 has been found to be a highly efficient and environmental friendly catalyst for the liquid-phase acylation of activated aromatic substrates giving aromatic ketones (45-93%) in a regioselective manner. Both aromatic and aliphatic carboxylic acids can be employed as acylating source. The process is particularly demonstrated at 100 g scale in the case of anisole and acetic acid to produce 4-methoxyacetophenone.

 


Keyword(s)

Friedel-Crafts acylations, phosphorus pentoxide, carboxylic acid, 4-methoxyacetophenone

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