Condensation of nicotinaldehydes with acetophenones and NH4OAc: A convenient synthesis and biological activities of 2',6'-diphenyl-3,4'-bipyridines

Bhimapaka, China Raju ; Begum, Shahnaz ; Rajeswari, B Uma ; Prakasham, R S ; Zehra, A ; Tiwari, A K


2',6'-Diphenyl-3,4'-bipyridines 3a-t have been achieved by the three-component, one-pot reaction of nicotinaldehydes 1a-b, acetophenones 2a-j and anhydrous ammonium acetate under solvent free conditions at 120°C. All the prepared compounds 3a-t have been screened for anti-microbial, free-radical scavenging and α-glucosidase inhibitory activities. Compounds 3m-r have shown anti-bacterial activity and compounds 3m-n identified as anti-fungal agents. Compounds 3d, 3h, 3m and 3r-s have shown α-glucosidase inhibitory activity.


Nicotinaldehydes, 2',6'-diphenyl-3,4'-bipyridines, anti-microbial activity, α-glucosidase inhibitory activity

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