Ultrasonicated synthesis of some potent antimicrobial aryl sulphonamides

Abstract

Nine N-(2,4-difluorophenyl) substituted benzene sulphonamides have been synthesized by ultrasonication method within short reaction time having more than 90% yield. These sulphonamides have been analyzed by spectral and analytical techniques. The higher yields of sulphonamides have been found to be in case of ultrasonication process as compared to microwave and conventional heating methods. The antimicrobial activities of these sulphonamides have been evaluated using Bauer-Kirby disc diffusion method by means of measurement of mm of zone of inhibition.