A simple and efficient one-pot synthesis of novel benzimidazo[1,2-a]- chromeno[4,3-d] pyrimidinones catalyzed by [Et3NH][HSO4]

Gumpula, Prasoona ; Baireddy, Kishore ; Gavaji, Brahmeshwari


A simple and efficient one-pot synthesis of novel polyheterocyclic benzimidazo[1,2-a]- chromeno[4,3-d]pyrimidinones 4 via a three-component condensation of 2-aminobenzimidazole 1, aromatic aldehydes 2 and 4-hydroxy coumarin 3 catalyzed by Bronsted acid ionic liquid triethyl ammonium hydrogen sulphate [Et3NH][HSO4] under solvent-free conditions is reported. The main advantages of this protocol are short reaction time, easy work-up, operational simplicity, and excellent yields with high purity, without intervention of chromatography.


Multi-component synthesis, benzimidazo[1,2-a]chromeno[4,3-d]pyrimidinones, polyheterocycles, triethyl ammonium hydrogen sulphate [TEAHS], solvent-free conditions

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