Free radical scavenging and α-glucosidase inhibitory activity of (E)-methyl/ethyl-3-(2-hydroxyphenyl)acrylates

 

Bhimapaka, China Raju ; Hariprasad, K Siva ; Harikrishna, G ; Tiwari, A K ; Zehra, A

Abstract

(E)-Methyl/ethyl-3-(2-hydroxyphenyl)acrylates 3a-x have been prepared by the reaction of salicylaldehydes 1a-l with Wittig reagents such as methyl (triphenylphosphoranylidene)acetate 2a and ethyl (triphenylphosphoranylidene)acetate 2b in dry DCM at room temperature. All the synthesized compounds have been evaluated for free-radical scavenging and α-glucosidase inhibitory activities. Compounds 3c and 3d display DPPH free radical scavenging activity. All the compounds have shown ABTS free radical scavenging activity except four compounds 3s-t and 3w-x. Compounds 3g, 3p and 3r display α-glucosidase inhibitory activity.

 


Keyword(s)

(E)-Methyl/ethyl-3-(2-hydroxyphenyl)acrylates, salicylaldehydes, free radical scavenging, α-glucosidase inhibitory activity


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