A green synthesis of isoquinolines using Ru(II)/PEG-400 as homogeneous recyclable catalyst via C-H/N-N bond activation

Nakkalwar, Shrinivas L; Kasralikar, Hanmant M; Kaminwar, Nitish S; Patwari, Shivaji B; Jadhav, Vivekanand B

Abstract

A novel and green synthesis of 1-phenyl isoquinoline derivatives has been developed by using Ru(II)/PEG-400 as homogeneous recyclable catalyst via C-H/N-N bond activation via C-H/N-N functionalization of 1-(diphenylmethylene) hydrazine and aryl substituted acetylenes. In order to realize the proposed protocol, Cu(OAc)2 and AgSbF6 are used as oxidant and additive respectively in PEG-400 biodegradable solvent. This protocol has a simple extraction procedure, uses biodegradable solvent, affords high atom economy, employs a reusable catalytic system, provides wide substrate scope with high yield of product, for the synthesis of isoquinoline derivatives.


Keyword(s)

Green synthesis, homogeneous catalyst, biodegradable solvent


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