Pivalic acid assisted Biginelli reaction for synthesis of dihydropyrimidinones and dihydrothiopyrimidinones

 

 

Kadam, Hari K; Gawas, Anushri Laxman; Vernekar, Shruti Sagun; Chodankar, Anika Arjun; Gaonkar, Saurabh Sudan; Salgaonkar, Lalitprabha N; Anveka, Tushar S; Vaz, Teotone ; Mhaldar, Shashank N

Abstract

Herein is provided an alternate, simple, multigram scale, efficient route for Biginelli reaction for synthesis of dihydropyrimidinones using urea, ethylacetatoacetate, and benzaldehyde with pivalic acid.

Keyword(s)

One-pot synthesis, green chemistry, heterocycles, bioactive compounds, pivalic acid, dihydropyrimidinones

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