Pivalic acid assisted Biginelli reaction for synthesis of dihydropyrimidinones and dihydrothiopyrimidinones
Herein is provided an alternate, simple, multigram scale, efficient route for Biginelli reaction for synthesis of dihydropyrimidinones using urea, ethylacetatoacetate, and benzaldehyde with pivalic acid.
One-pot synthesis, green chemistry, heterocycles, bioactive compounds, pivalic acid, dihydropyrimidinones
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