Synthesis, anti-tuberculosis and anti-bacterial activities of sulfonamide bearing
4-((2-(5-bromo-1H-pyrazolo[3,4-b]pyridin-1-yl)-2-oxoethyl)amino)-N-(various substitutions)benzenesulfonamide

Variy, Hiren H; Panchal, Vikram ; Patel, G R

Abstract

In this study all the new synthesized compounds of sulfonamide bearing 4-((2-(5-bromo-1H-pyrazolo[3,4-b]pyridin-1-yl)-2-oxoethyl)amino)-N-(various-substitutions)benzenesul-fonamide have been synthesized by using 1-(5-bromo-1H-pyarazolo[3,4-b]pyridin-1yl)-2-chloroethanone which has been fused with various sulfa drugs in presence of potassium carbonate and DMF. All the derivatives have been recognized by physical properties like melting point and characterization by elemental analysis (CHNS) and various spectral techniques such as FT-IR, 1H and 13C NMR, and ESI-MS. The series of these pyrazolo[3,4-b]pyridin bearing sulfonamide have been synthesized and the final derivatives have been evaluated for bioactivity such as anti-bacterial activity against gram +ve and gram −ve and also screened for their in vitro anti tubercular activity against Mycobacterium tuberculosis H37RV. The results for the synthesized compounds have been compared against standard drugs.

Keyword(s)

1H-Pyarazolo[3,4-b]pyridin, sulfonamide, in vitro anti-tuberculosis, anti-bacterial activity, spectral studies

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