A convenient metal free approach towards the synthesis of dihydropyrimidones mediated by achiral nicotinic acid without solvent

 

Roy, Harendra Nath; Imon, Mohinuddin Khan; Islam, Md. Nazrul; Kamma, Koteswara R

Abstract

A very simple arrangement of Biginelli’s condensation reaction of 1,3-dicarbonyl compound, aromatic / aliphatic aldehyde and urea / thiourea has been performed in a convenient way by using nicotinic acid without any solvent and under ambient conditions. This approach of pyrimidone synthesis is simple, versatile, metal-free, high yielding and environmentally benign.

 


Keyword(s)

Dihydropyrimidones, nicotinic acid, solvent-free, N-heterocycles, metal-free


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