Preparation of Ibuprofen chitosan/montmorillonite microspheres by ionic cross-linking under microwave irradiation

Liu, Xue-gui

Abstract

Ibuprofen chitosan (CS) /montmorillonite (MMT) microspheres have been produced by an ion cross-linking technique under microwave irradiation. The morphology and mechanical strength of the microspheres are significantly improved due to the use of chitosan as a drug carrier. Also, in comparison with other cross linker reagents, the effect of adsorption can be increased by the use of a small amount of sodium pyrophosphate. Furthermore, an orthogonal design method has been applied in order to obtain the optimal conditions for microsphere production, and the results are as follows: the reaction temperature is 60°C, the amount of montmorillonite added is 13%, the amount of ibuprofen added is 10%, the mole ratio of cation to anion is 50:1, and the entrapment efficiency is 49.70%. The structure, mechanical strength and characteristic infrared peaks of the microspheres have been examined by scanning electron microscopy (SEM), thermogravimetric analysis (TG) and Fourier transform infrared spectroscopy (FTIR), respectively.

Keyword(s)

Ca-montmorillonite; CS/MMT microspheres; Ion cross-linking technique; Orthogonal design method; Sodium pyrophosphate

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