Voltammetric investigations of functional dyspepsia drug acotiamide at pencil graphite electrode: An eco-friendly and cost effective stripping detection method

Jhankal, Krishna Kumar; AGARWAL, RINKY ; YADAV, RAJESH ; SHARMA, D. K. ; SHARMA, RAJ KUMAR

Abstract

First time, the electro-oxidative behaviour and determination of acotiamide at a pencil graphite electrode have been investigated under different experimental conditions using cyclic voltammetry (CV), differential pulse anodic stripping voltammetry (DPASV), and square wave anodic stripping voltammetric (SWASV) techniques. The voltammetric responses of acotiamide have been analyzed at different scan rates, pH and concentrations. Oxidation of acotiamide at the surface of pencil graphite electrode gave two well defined irreversible peaks in the voltammograms in BR buffer of pH 7.0. The oxidation process is completely diffusion controlled. A linear response of peak current has been obtained between 15.5 to 124 μM in non-aqueous media for all the voltammetric techniques. The proposed DPASV and SWASV techniques show limit of detection at 18.58 and 13.36 μM, respectively.


Keyword(s)

Acotiamide; BR buffer; Functional dyspepsia; Pencil graphite electrode; Stripping voltammetry


Full Text: PDF (downloaded 457 times)

Refbacks

  • There are currently no refbacks.
This abstract viewed 829 times