Synthesis and characterization of highly substituted pyrazoles using silicaphosphoric acid nanoparticles as a recoverable heterogeneous solid acid catalyst

Yaghmaeiyan, Nahid ; Bamoniri, Abdolhamid ; Khaje, Somayeh


Highly substituted pyrazoles have been prepared by condensing 1,3-diketones and various hydrazine derivatives using silica-phosphoric acid nanoparticles (nano-SPA). This nano solid catalyst has been prepared by the reaction of nano silica chloride with dry phosphoric acid. This green methodology has advantages such as short reaction times, simple work-up, high efficiency, reusability of the catalyst and no use of any solvents.


Highly substituted pyrazoles; Heterogeneous; Nano silica-phosphoric acid; Solid acid catalyst

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