Expression and correlation of PBRM1 and P53 in clear cell carcinoma of kidney

Zhang, Qi ; Zhang, Zhiyu ; Xu, Yingkun ; Chen, Yougen

Abstract

Prevalence of clear cell renal cell carcinoma (ccRCC) among human population though common among adults, it occurs in children and young adults as well. The prognostic value of P53 expression in ccRCC is well known. Recently, PBRM1 has also acquired attention for its prognostic and predictive value in ccRCC. Here, we investigated the expression and correlation of PBRM1 and P53 in ccRCC. Renal tissues were collected from 70 patients who have undergone radical nephrectomy for clear cell carcinoma of the kidney in our hospital and 24 healthy volunteers for the study. We used immunohistochemical approach to determine the expression of PBRM1 and P53 in clear cell carcinoma of the kidney and normal kidney tissues and to analyze the correlation between them. Clinicopathological parameters and prognosis of patients were also studied. The positive expression rate of PBRM1 in clear renal cell carcinoma tissues was significantly higher (62.86%) compared to the normal renal tissues 8.33%. Similarly, positive expression rate of P53 in clear renal cell carcinoma tissues was 40%, while it was no expression in normal renal tissues. The expression level of PBRM1 was correlated with pathological grade and clinical stage of ccRCC patients, but not with age, sex and tumor size. P53 and expression levels were independent of age, sex, tumor size, pathological grade, and clinical stage of patients with clear cell carcinoma of the kidney. The 5-year survival rate of PBRM1 positive expression patients was 40.91% significantly lower than that of PBRM1 negative expression patients (84.62%), whereas in P53 it was 50 and 61.90%, respectively. Clinical stage, pathological grade and PBRM1 were all independent risk factors affecting the prognosis of patients with clear cell carcinoma of the kidney. Overall, the results suggest that PBRM1 is positively correlated with P53 in clear cell carcinoma of kidney (r=0.781, P=0.012). PBRM1 and P53 are both highly expressed in ccRCC and play an important role in the development of the disease. PBRM1 can also be used as an independent risk factor affecting the prognosis of ccRCC patients.

Keyword(s)

Clear cell Renal carcinoma; Kidney cancer

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