Novel composite meshes to evaluate their structural property and in vivo biocompatibility for tissue repair

Lu, Yao ; Fu, Shaoju ; Hu, Bing ; Cheng, Ge ; Li, Nannan ; Zhou, Shuanglin

Abstract

Composite meshes of different types have been prepared and used for tissue repair in pelvic floor disorder. An interlocking texture mesh (inter-mesh) and a membrane coated mesh (electro-mesh) have been used based on their structural property and biocompatibility. The proportion of degradation material in inter-mesh (69.6%) is found extremely higher than that of electro-mesh (3.22%), thus leading to higher product weight (65.50±2.31 g/m2) and thickness (0.500±0.025 mm). After 4 weeks of implantation in animal experiment, inter-mesh with surrounding tissues is observed to have higher breaking strength in tensile behavoir and better flexibility. Tissues on inter-mesh are found to grow faster with larger thickness (0.76±0.033 mm). The surface area loss of inter-mesh (2.49±0.25%) is much less than that of electro-mesh (7.49±0.63 %) within the first 2 weeks of implantation. However, the material’s degradation is accelerated after 2 weeks, leading to a higher shrinkage of 13.12±1.48 %.


Keyword(s)

Biocompatibility;Electrospinning;Elctro-mesh;Interlocking texture;Inter-mesh;Pelvic floor repair;Polypropylene mesh;Polylactic acid mesh

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