Protective effect of ethanolic extract of Psidium guajava L. leaves in tacrine-induced orofacial dyskinesia by assessing its neurobehavioral and biochemical alterations in rats

Abstract

The present study investigated the protective effect of the ethanolic extract of Psidium guajava L. against tacrine-induced orofacial dyskinesia in rats. Behavioral assessments such as vacuous chewing movements, tongue protrusions, orofacial bursts, locomotion, and cognition were recorded. Forebrain of tacrine treated animals was assessed for its antioxidant levels. P. guajava (100 and 200 mg/kg, p.o.) significantly (P <0.05) inhibited tacrine induced vacuous chewing movements, tongue protrusions, orofacial bursts and significantly (P <0.05) increased locomotion and cognition. Treatment with P. guajava (100 and 200 mg/kg, p.o.) exhibited significant elevation in the levels of superoxide dismutase, catalase, glutathione reductase and inhibition of lipid peroxidation in the forebrain region as compared to the tacrine treated group of animals. Results suggest that P. guajava extract (100 and 200 mg/kg) has good potential to ameliorate tacrine induced orofacial dyskinesia.