Synergistic effect of propolis with cefixime against Salmonella enterica serovar Typhimurium: An in vitro study

Abstract

Antibiotic resistance is one of the world’s most pressing health problems in 21st century. Multi Drug Resistance (MDR) is a phenomenon where the microorganism develops resistance against more than one drug. MDR typhoid is one such emerging problem. This calls for some alternative drugs or use of some compounds alone or in combination with drugs against typhoid. Apitherapy provide us the cure for this. In apitherapy, the honey bee and its hive products are used for the treatment for various ailments. In the present study, a honey bee product i.e. propolis which act as a strong antibacterial is combined with standard antibiotic i.e. cefixime against Salmonella. The time kill analysis and results of checkerboard method confirmed when propolis and cefixime were used in combination, synergy was observed.