Gene silencing and gene drive in dengue vector control

Paulraj, Michael Gabriel; Ignacimuthu, Savarimuthu ; Reegan, Appadurai Daniel

Abstract

Vector-borne diseases are the most feared diseases throughout the world. Mosquitoes are the prime human disease vectors as they are responsible for nearly one million human deaths every year. So they are declared as the most dangerous insects to mankind. Aedes aegypti and Ae. albopictus are the most significant mosquito species, because of their role in transmitting dengue virus. These blood feeding ectoparasites of man and other vertebrates have developed excellent adaptations to survive and multiply in and around human habitations. Chemical-based mosquito control method does not give good results due to rapid development of pesticide resistance in mosquitoes. The past four decades have witnessed the development of several alternate mosquito control methods. Genetic control technologies have been recently developed as efficient and ecofriendly methods. Inundate release of genetically modified mosquitoes with lethal or pathogen-resistant genes for population reduction is a recent technology in mosquito control programme. Recent developments in molecular and genome editing technologies have made it easy to produce thousands of transgenic mosquitoes for field release. The present review highlights various scientific reports and research findings on gene silencing and gene drive techniques in dengue mosquito control.

Keyword(s)

CRISPR/Cas9, Dengue, Genome Editing, miRNA, RNAi, siRNA.

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