Antimycobacterial activity of linoleic acid and oleic acid obtained from the hexane extract of the seeds of Mesua ferrea L. and their in silico investigation

Kalita, Ranjan Dutta; Hussain, Iftikar ; Deka, Ramesh C; Buragohain, Alak Kumar

Abstract

Tuberculosis is responsible for about 8 million deaths worldwide annually. The emergence of multidrug-resistant and extensively drug-resistant strains urgently requires the development of new drugs against tuberculosis. Drug discovery from plants against tuberculosis is an exciting area for exploration. In the present study, the fatty acids- linoleic and oleic acids isolated and identified from the seeds of the plant Mesua ferrea L. exhibited antimycobacterial activity. The analysis was done using Gas Chromatography-Mass Spectrometry and supplementary information was obtained using fourier transform-infra red and 1H and 13C nuclear magnetic resonance. The minimum inhibitory concentration of the purified fraction containing both the compounds was found to be 78 µg/mL. In silico molecular docking studies against the target proteins GlfT2, Inh A and mtKasB of Mycobacterium tuberculosis revealed high scores for both the compounds. Cytotoxicity studies of the compounds revealed no toxicity and high antioxidant activity was observed.


Keyword(s)

Antituberculosis; Cytotoxicity; Docking; Medicinal plants; Mesua ferrea L


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