Protective effect of Psidium guajava L. leaves ethanolic extract on doxorubicin-induced nephrotoxicity in rats

Abstract

The objective of the present study was to investigate the protective effect of ethanolic extract of Psidium guajava L. leaves against doxorubicin-induced nephrotoxicity in rats. Animals treated with doxorubicin (8mg/kg, i.p) once daily for 2 days significantly (P<0.05) increased Serum Urea, BUN, creatinine, total protein, LPO and significantly (P<0.05) decreased CAT, SOD, GSH levels as compared to vehicle treated rats. Treatment with P. guajava (100 & 300 mg/kg, p.o) showed significant (P<0.05) decrease in Serum Urea, BUN, creatinine, total protein, LPO and significant (P<0.05) increase in CAT, SOD, GSH levels as compared to doxorubicin treated group. Histopathological examinations of kidney tissue showed that doxorubicin changed the renal architecture significantly which was less evident in P. guajava (100 mg/kg & 300 mg/kg) pre-treated rats. Results suggest that P. guajava extract has the potential to ameliorate doxorubicin induced nephrotoxicity and might serve as a novel combination agent with doxorubicin to limit renal damage.