Hepatoprotective activity of Ficus semicordata Buch.-Ham. ex Sm. leaves aqueous extract on D-galactosamine induced toxicity in HepG2 cell line

Gupta, Shashi ; Ranade, Anagha ; Gayakwad, Shivani ; Acharya, Rabinarayan ; Pawar, Sharad

Abstract

The leaves of Ficus semicordata Buch-Ham.ex Sm., locally in North India is referred to as Bhumi udumbara have been reported for their traditional use to cure jaundice and various liver ailments. Despite its extensive usage in northeastern states of India, there is a lack of scientific substantiation on the safety and pharmacotherapeutic efficacy. The present study was carried out to evaluate the hepatoprotective activity of F. semicordata (FS) leaves aqueous extract on HepG2 cell line to validate its ethnic claim in the management of liver disorders. D-galactosamine induced HepG2 cell toxicity model was used to evaluate its hepatoprotective activity. The cells were treated with different concentrations of aqueous extracts and dexamethasone as a standard. MTT assay was performed to determine the % inhibition of hepatotoxicity. The result indicates that the toxicity induced by D-galactosamine is reduced by FS aqueous extract group which is better when compared with the standard drug. This study revealed the hepatoprotective potential of F. semicordata on HepG2 cell line

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Keyword(s)

D-galactosamine, Dexamethasone, Ficus semicordata Buch. Ham. ex Sm, Hepatoprotective, HepG2.

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