Aquilaria species as potential anti-inflammatory agents–A review on in vitro and in vivo studies

Eissa, Manar A.; Hashim, Yumi Z.H-Y; Salleh, Hamzah Mohd.; Abd-Azziz, Saripah S.S; Isa, Muhammad Lokman Md.; Abd Warif, Nor Malia ; Nor, Yusilawati Ahmad; El-Kersh, Dina M.; Sani, Shirwan Abdullah


In the current review article, the studies conducted to investigate the anti-inflammatory activity of Aquilaria species are compiled and summarized. Since inflammation is the underlying cause of many diseases, the encounter of effective and safe biomedical anti-inflammatory compounds has become the focus of recent researches. Aquilaria species were known to possess a wide spectrum of pharmacological activities, among which anti-inflammatory activity has been reported in many in vitro and in vivo studies. Chromones, sesquiterpenoids, flavonoids, benzophenones and phorbol esters were the major anti-inflammatory compounds isolated from Aquilaria species. The objective of this review paper is to extend researches on the anti-inflammatory activity of different parts of Aquilaria species and support their future use in natural pharmaceutical preparations for the treatment of inflammation-associated conditions.


Aquilaria; Agarwood; Inflammation; Anti-inflammatory; Secondary metabolites

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