A study of acute dermal toxicity of Artemisia herba-alba Asso essential oils

Boukhennoufa, Asma ; Boumediene, Meddah ; Aicha, Tir Touil Meddah


Medicinal plants constitute a huge reserve of many therapeutic virtues recognized by their powerful effects since the dawn of time. Our research focused on the study of acute skin toxicity (AST) of Artemisia herba-alba Asso (Aha) essential oils, obtained by hydrodistillation. AST has been evaluated, using rats of the species Rattus norvegicus with reference to a method proposed by the organisation for economic co-operation and development (OECD) guideline. Biochemical parameters, alanine aminotransferase, aspartate aminotransférase, total bilirubin, direct bilirubin, and creatinine were measured in whole blood after animal sacrifices. In parallel, the histological liver and kidney sections were analyzed. The Lethal dose50 (LD50) value was found greater than 5000 mg/kg. In addition, the biochemical markers of the tested rats did not change during the experiment compared to the control group. No tissue damage has been detected. A. herba alba Asso essential oil was considered non-dangerous, which can be used to heal against all benign or severe illnesses.


Acute skin toxicity; Artemisia herba-alba Asso; Essential oils; LD50. university of Mascara

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