Cloning and sequencing of α-2u globulin of rat preputial gland to assess its longevity in the context of developing an effective rodent trap

Silambarasan, V ; Gayathiri, S ; Deepalakshmi, G ; Shahitha Banu, M ; Nithya, V ; Archunan, G


α-2u globulin, a pheromone binding protein found majorly in the preputial gland, was reported to involve in chemo-communication of rats. The biosynthesis of this pheromone binding protein is under complex multihormonal control and its regulation takes place at transcription level. Assessing and increasing the longevity of this protein may retain the volatility of pheromone. So far nearly 20 isoforms of α-2u globulin in rat have been studied. The present study was aimed to extend the longevity of pheromone compound by cloning and sequencing of the mRNA which codes for α-2u globulin in the preputial gland of Rattus novergicus. Unexpectedly, this study resulted in a new isoform, which is similar in function with α-2u globulin protein with some different exons removed. Further analysis with this isoform may pave a way for rodent pest management.


Isoform; Pheromone binding protein; Preputial gland; Rat trap

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