Design, synthesis and characterization of novel fluorinated styryl chromones


Kundlikar, S G ; Jojar, P J ; Tarade, M S ; Thorat, Y R ; Thube, D R ; Karale, B K ; Akolkar, H N ; Mhaske, S D

Abstract

(E)-3-(3-(Trifluoromethyl)-5-nitrophenyl)acrylic acid 1 when treated with substituted 2-hydroxyacetophenones 2 in dry pyridine and POCl3 affords compound 3 which when reacted with pyridine/KOH by B. V. transformation gives 4. Compound 4 on refluxing with acetic acid in HCl gives 5. The structures of all synthesized compounds have been confirmed by spectroscopic techniques.


Keyword(s)

Fluorine, diketone, styryl chromones



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