Microwave assisted synthesis of heterocyclic metal complexes and evaluation of their in vitro anticancer activity against oral cancer cells, antioxidant and molecular docking study

Abstract

Heterocyclic complexes of Cr(III) and Fe(III) have been synthesized through condensation of succinic dihydrazide with 5-chloroindoline-2,3-dione in alcoholic medium by template method in 1:1:1 ratio using microwave irradiation technique. On the basis of physicochemical and spectroscopic techniques the geometry of the complexes are identified as octahedral. The synthesized complexes are screened for their bioactivity. In vitro anticancer activity was evaluated against HNSC cell line and antioxidant activity is done by DPPH assay method. In-silico study is done by molecular docking with EGFR tyrosine kinase. The results show that synthesized compounds have significant anticancer as well as antioxidant property.