Synthesis, characterization and antimicrobial studies of (E)-N-((2-chloro-6-substituted quinolin-3-yl)methylene)-4-(substituted phenyl)-6-phenyl-2H-1,3-oxazin-2-amines

Abstract

Research work is planned to synthesize novel (E)-N-((2-chloro-6-substituted quinolin-3-yl)methylene)-4-(substituted phenyl)-6-phenyl-2H-1,3-oxazin-2-amines by the reaction of 6-(3-substituted phenyl)-4-(4-substituted phenyl)-5,6-dihydro-4H-1,3-oxazin-2-amines with 6-substituted-2-chloro-quinoline-3-carbaldehydes in alcoholic medium and in the presence of acetic acid. The structures of synthesized compounds are assigned on the basis of FT-IR, ¹H-NMR, ¹³C-NMR and Mass spectral data. The new compounds are also screened for their antibacterial and antifungal activities. These compounds are showing potent antimicrobial activities due to their chemical structure.