Synthesis, structural characterization and biological aspects of divalent transition metal complexes derived from 2, 5 diacetry furan and 2-thia-6-aza-bicyclo [4.2.0]oct-4-en-7-one based schiff base.

Abstract

Biologically active dinuclear complexes [M₂(C₄₄H₅₂N₂₀O₂S₈)X₄] of Cu(II), Ni(II) and Co(II) with Schiff base ligand (C₂₂H₂₆N₁₀OS₄) got through the buildup of 2,5 diethylidene furan bis (thiocarbohydrazide) with 2-thia-6-aza-bicyclo[4.2.0]oct-4-en-7-one. The recently orchestrated Schiff base and its metal derivatives have been basically portrayed with the assistance of elemental analysis, condensation measurement, magnetic measurement and their structure configuration explain with the help of different spectroscopic (electronic, IR, ¹H NMR, ¹³C NMR, GCMS) systems. The electronic spectra of the metal complexes (metal ligand derivatives) demonstrate an octahedral geometry of the middle metal ion. These ligand and its metal derivatives were screened for their Antioxidant and antimicrobial hindering potential and compared with standard medications butylated hydroxyanisol (free radical searching active), Imipenem (antibacterial) and Miconazole (antifungal). [Ni₂(C₄₄H₅₂N₂₀O₂S₈)(OAc)₄] demonstrates best antimicrobial action against the contemplated microorganism, and [Cu₂(C₄₄H₅₂N₂₀O₂S₈)(OAc)₄] demonstrates the best free radical searching action.