Synthesis of biologically active 2-thio-5-arylbenzo[4,5]thiazolopyrimido [5,4-d]pyrimidin-4-one derivatives catalyzed by metal proline in water

Abstract

A facile and highly efficient one pot multi-component reaction for the synthesis of 2-thio-5-arylbenzo
[4,5]thiazolopyrimido[5,4-d]pyrimidin-4-one derivatives 4 under aqueous medium has been developed. The reaction takes place by condensation of thiobarbituric acids 1, 2-aminobenzothiazole 2 and aldehydes 3 using metal-proline catalyzed domino Knoevenagel, Michael and intramolecular cyclization approach.