An efficient solvent-free synthesis of pyrido[2,3-d]pyrimidine derivatives utilizing lactic acid as green and eco-friendly catalyst

 

Safarzaei, Mohyeddin ; Mollashahi, Ebrahim ; Lashkari, Mojtaba ; Maghsoodlou, Malek Taher; Hazeri, Nourallah

Abstract

An efficient, solvent-free and one-pot procedure for the synthesis of pyrido[2,3-d]pyrimidine derivatives by condensation of aromatic aldehydes, malononitrile and 6-amino-1,3-dimethyl uracil at 90°C catalyzed by lactic acid as an inexpensive, biological and eco-friendly compound is described. The remarkable benefits of this procedure are green and environmentally friendly reaction conditions, high yields, short reaction time, simple methodology and easy workup.



Keyword(s)

Lactic acid, 6-amino-1,3-dimethyluracil, aryl aldehyde, malononitrile, solvent-free conditions

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