An efficient synthesis, invitro and insilco evaluation of new pyrazole and isoxazole derivatives as anti-inflammatory agents

Abstract

The present study is the synthesis of new heterocyclic moieties like pyrazole, isoxazole and thiazole containing benzimidazole nucleus. The title compounds were synthesized from 4-(1H-benzo[d]imidazol-2-yl) oxazol-2-amine. The newly synthesised compounds were screened for their in vitro anti-inflammatory activity and demonstrated excellent to moderate activity and molecular docking study reports are supporting anti-inflammatory activity showed high inhibition constant and binding energy. The structures of synthesised compounds were characterized by IR, 1HNMR, Mass spectroscopic methods.